The Penicillin Cocktail: A Cure-All for Your Thirst
Sophia
Updated 09/01/2025
Introduction 🥃
The Penicillin cocktail isn't your grandmother's cough syrup (though it might just cure what's bothering you better than anything from her medicine cabinet). This modern classic combines the warming embrace of Scotch whisky with the zing of fresh ginger and lemon, topped off with a mysterious smoky float that'll make you forget all about your troubles.
Unlike its pharmaceutical namesake, this Penicillin won't require a prescription, though you might find yourself becoming dangerously addicted to its complex, soul-warming flavors.
The Legend Behind the Penicillin Cocktail 📜
This cocktail earned worldwide fame because it's brilliant in its simplicity and flavor. This liquid masterpiece was born in 2005 at the legendary Milk & Honey bar in New York City, created by the brilliant Australian bartender Sam Ross. Ross wasn't trying to reinvent the wheel; he was simply craving something that combined his love for Scotch with the comforting flavors of honey and ginger. The result was pure genius, a drink that bridges the gap between classic cocktail craftsmanship and modern innovation.
The name "Penicillin" was a perfect fit. It's a nod to the healing properties of the honey-ginger combo (a common home remedy for sore throats) and the fact that the smoky Scotch "infects" the entire drink with its deliciously peaty flavor. It spread through the cocktail world like a… well, like a good virus, quickly becoming a staple on craft cocktail menus worldwide.
Penicillin Cocktail Recipe 📊
Ingredients 📋
| Ingredient | Measurement |
|---|---|
| Blended Scotch Whisky | 2 oz |
| Fresh Lemon Juice | ¾ oz |
| Honey‑ginger syrup | ¾ oz |
| Islay Single Malt Scotch | ¼ oz |
| Ice | As needed |
| Garnish | Candied ginger |
Honey‑ginger syrup: Combine equal parts honey and water (e.g., 1 cup each) with a 6‑inch piece of peeled, sliced fresh ginger. Boil briefly, simmer 5 minutes, then chill and strain.
Step-by-step recipe 🧪
- In a shaker filled with ice, combine the Blended Scotch Whisky, fresh lemon juice, and honey-ginger syrup.
- Shake vigorously until well-chilled.
- Double-strain into a chilled rocks glass over fresh ice.
- Gently float the Islay Single Malt Scotch on top by pouring it slowly over the back of a bar spoon.
- Garnish with a piece of candied ginger.
Decoding the Classic Charm of the Penicillin Cocktail 🕵️♂
The Penicillin isn't just popular; it's a perfectly balanced masterpiece of flavor and aroma. Its charm lies in its journey of taste.
- The Aroma: Before you even take a sip, the smoky, briny, and medicinal aroma of the Islay Scotch float wafts up. It's intriguing, bold, and absolutely mouthwatering.
- The First Sip: As you drink, your palate is first met by the smooth, approachable sweetness of the blended Scotch and honey-ginger syrup.
- The Complex Finish: Then, the sharp, cleansing acidity of the lemon cuts through, followed by the lingering, warm, and peaty smoke from the float. It's a rollercoaster of sweet, sour, spicy, and smoky that is incredibly satisfying .
Fun Facts 🤓
- The Ginger Connection: The honey-ginger syrup isn't just delicious, it actually does have genuine medicinal properties. Ginger has been used for centuries to treat nausea and inflammation, so you're basically taking medicine... that happens to contain alcohol.
- The Smoke Show: The Islay Scotch float isn't just for show, it fundamentally changes how you experience the drink. Your sense of smell accounts for about 80% of taste, so that peaty aroma primes your palate for the complex flavors below.
- A Modern Classic: It's one of the few cocktails invented after the year 2000 to achieve widespread classic status. It's basically the Millennial of the cocktail world.
- The Therapeutic Effect: Bartenders swear by the Penicillin's ability to cure everything from heartbreak to the common cold. While we can't guarantee medical results, we can promise it'll make whatever's bothering you feel at least 50% less important.
Frequently Asked Questions About the Penicillin cocktail(FAQs) 🕵️
1. Is the Penicillin cocktail actually good for a cold?
It tastes comforting because ginger, honey, and lemon are cozy flavors, but it is still an alcoholic drink, so treat it as a morale booster, not medicine.
2. Can I use store bought ginger syrup for Penicillin cocktail?
You can, but store bought ginger syrup often lacks the spicy punch of fresh ginger. Making it yourself is worth the effort.
3. What Scotch Whisky should I use for my Penicillin cocktail?
Use a blended Scotch that is smooth and not overly peaty. Popular choices include Monkey Shoulder, Famous Grouse, Compass Box Great King Street, or Bank Note.
4. What Islay Scotch works best for my Penicillin cocktail?
Choose a peaty Islay Scotch you enjoy nosing. Even a small float is very aromatic, so pick something that smells great to you.
5. How long does Honey‑ginger syrup last?
When properly stored in an airtight container in the refrigerator, honey ginger syrup will last about two weeks. The honey acts as a natural preservative, but the fresh ginger means it won't last as long as simple syrup. If you notice any cloudiness, off smells, or mold, discard it immediately and make a fresh batch.
6. My Penicillin cocktail is too spicy or too sweet, how do I fix it?
For less heat, reduce ginger intensity in the syrup or use a smaller Honey‑ginger syrup measure next time. For less sweetness, keep Honey‑ginger syrup the same but add a tiny touch more lemon.
7. Can I skip the float step for my Penicillin cocktail?
You can, but you lose the signature smoky aroma. The float is the little theatrical moment that makes the Penicillin feel like itself.
8. Why is the cocktail called Penicillin?
The honey and ginger have long been used as home remedies for colds and sore throats. The name nods to the comforting, like vibe of honey and ginger, with a wink toward feeling better. It is cocktail humor, not a prescription.
9. Can I use bottled lemon juice for my Penicillin cocktail?
Please don't. Fresh lemon juice is absolutely essential to this cocktail. Bottled lemon juice has a flat, bitter quality that will completely throw off the balance. Fresh lemon takes seconds to juice and makes an enormous difference in the final drink.
10. What if I don't like ginger?
The ginger in this cocktail is more subtle than you might think. The honey rounds it out and the Scotch mellows it. However, if you truly dislike ginger, you could try making a plain honey syrup instead, though you'll lose some of the drink's complexity and warming quality.
11. Can I batch Penicillin cocktails for a party?
Absolutely! Multiply the base ingredients (Scotch Whisky, lemon juice, honey-ginger syrup) by however many servings you need, but don't add ice or dilution. When serving, shake individual portions with ice or stir the batch with ice to achieve proper dilution and chill. Add the peated Scotch float to each individual glass for the best presentation and aroma.
References:
[1]: https://www.epicurious.com/recipes/food/views/penicillin-cocktail-scotch-ginger
[2]: https://iba-world.com/iba-cocktail/penicillin/
[3]: https://www.thewhiskyexchange.com/inspiration/article/18135/how-to-make-a-penicillin-cocktail
[4]: https://cluboenologique.com/story/anatomy-of-penicillin-cocktail/















